ECM provides an interdisciplinary forum for publication of preclinical research in the musculoskeletal field (Orthopaedics, Trauma, Maxillofacial (including dental) and Spine). ECM Journal is published by the AO Research Institute Davos, a Not-for-Profit foundation in Switzerland.? Assessment of materials for biomedical useManuscripts must have an important biological dimension, reporting effects at the cellular, tissue or organismic levels. Mechanotransduction papers with musculoskeletal cells are within ECM scope. In vitro cytocompatibilty studies should use primary cells or more than one cell line and provide more than just simple descriptions of cell viability, spreading, proliferation, mineralisation etc. Major improvements with in vitro, ex vivo or in vivo models and relevant opinion papers may be considered. Papers focussing purely on material properties or biomechanics properties (alone or combined, without a strong biological dimension) will not be entertained. Manuscripts on effects of surfaces, coatings, additives etc. in preventing bacterial adhesion must also consider the effect on eukaryotic cells (to be mentioned within the abstract) or refer to previously published data using the exact same surfaces. High level submissions on infection prevention, diagnostics, therapy and major improvement with in vitro or in vivo models within the musculoskeletal field (as defined by ECM below) are within ECM scope.? Tissue Engineering and Regenerative Medicine (TERM)Manuscripts concerning aspects of the repair or regeneration of connective and mineralized tissues within the musculoskeletal field (as defined by ECM below) will be considered. TERM papers where only biomechanical testing is utilized will not be considered, but biomechanics may be within a TERM submission.? Structure, function, biology and biomechanics of connective and mineralized tissuesManuscripts concerning the structure of bone, teeth, cartilage, intervertebral discs, skeletal muscle, tendons and ligaments within the musculoskeletal field (as defined by ECM below) will be considered.? Stem and Progenitor CellsManuscripts concerning stem cell characterization and mechanisms of differentiation as they relate to the connective and mineralized tissues of the musculoskeletal field (as defined by ECM below) will be considered. Note: The use of pooled donor cells should be avoided. When unavoidable, their use needs to be justified convincingly within the manuscript (and within the cover letter). Note: Technical notes and papers focussing purely on computational, material or biomechanical models will not be entertained. Papers must report effects at the cellular, tissue or organismic levels, which is a pre-requisite for possible acceptance of papers for publication in ECM.The clinical relevance of the work must be briefly mentioned within the abstract and in more detail in the paper. Poor abstracts, which do not concisely cover the paper contents will not be sent for review. Incremental steps in research will not be entertained by ECM journal. Cross-disciplinary papers that go across our scope areas are within ECM scope.ECM 's definition of the musculoskeletal field includes bone, teeth, cartilage, intervertebral discs, skeletal muscle (not smooth or cardiac muscle), tendons and ligaments (it does not include the spinal cord or neural tissues).

ECM為肌肉骨骼領域（骨科、創(chuàng)傷、頜面（包括牙科）和脊柱）的臨床前研究提供了一個跨學科論壇。ECM期刊是由AO研究所DavOS，瑞士的非營利基金會出版的。生物醫(yī)學用材料評估手稿必須有一個重要的生物學維度，在細胞、組織或組織層面上報告效果。肌肉骨骼細胞的機械轉(zhuǎn)導紙在ECM范圍內(nèi)。體外細胞相容性研究應使用原代細胞或多個細胞系，并提供細胞活力、擴散、增殖、礦化等的簡單描述。可考慮對體外、體外或體內(nèi)模型和相關(guān)意見文件進行重大改進。僅關(guān)注材料特性或生物力學特性（單獨或組合，沒有強大的生物學維度）的論文將不受歡迎。在防止細菌粘附方面，有關(guān)表面、涂層、添加劑等影響的手稿還必須考慮對真核細胞的影響（在摘要中提及），或參考使用完全相同表面的先前發(fā)布的數(shù)據(jù)。有關(guān)肌肉骨骼領域（定義見下文）內(nèi)的體外或體內(nèi)模型的感染預防、診斷、治療和重大改進的高水平提交資料在ECM范圍內(nèi)。?組織工程和再生醫(yī)學（學期）將考慮有關(guān)肌肉骨骼領域內(nèi)結(jié)締組織和礦化組織修復或再生方面的手稿（見下文ECM的定義）。只使用生物力學測試的學期論文將不予考慮，但生物力學可以在學期內(nèi)提交。?結(jié)締組織和礦化組織的結(jié)構(gòu)、功能、生物學和生物力學將考慮有關(guān)骨骼、牙齒、軟骨、椎間盤、骨骼肌、肌腱和肌肉骨骼場（定義見下文ECM）內(nèi)韌帶結(jié)構(gòu)的手稿。?干細胞和祖細胞將考慮有關(guān)干細胞特征和分化機制的手稿，因為它們與肌肉骨骼場的結(jié)締組織和礦化組織有關(guān)（如下面的ECM所定義）。注意：應避免使用集合供者細胞。在不可避免的情況下，它們的使用需要在手稿（以及附信）中得到令人信服的證明。注：僅關(guān)注計算模型、材料模型或生物力學模型的技術(shù)說明和論文將不予受理。論文必須報告細胞、組織或組織水平的影響，這是可能接受在ECM中發(fā)表論文的先決條件。必須在摘要中簡要提及這項工作的臨床相關(guān)性，并在本文中進行更詳細的介紹。摘要不好，不能簡明扼要地覆蓋論文內(nèi)容，將不送審。《電子商務雜志》不接受研究中的增量步驟。跨范圍的跨學科論文在ECM范圍內(nèi)。ECM對肌肉骨骼場的定義包括骨骼、牙齒、軟骨、椎間盤、骨骼肌（非平滑肌或心肌）、肌腱和韌帶（不包括脊髓或神經(jīng)組織）。