Clinical Therapeutics provides peer-reviewed, rapid publication of recent developments in drug and other therapies as well as in pharmacoeconomics, health policy, treatment outcomes, and innovations in drug and biologics research. In addition Clinical Therapeutics features updates on specific topics collated by expert Topic Editors. Clinical Therapeutics is read by a large international audience of scientists and clinicians in a variety of research, academic, and clinical practice settings. Articles are indexed by all major biomedical abstracting databases.Published articles range from pivotal studies exploring new chemical entities in large, multicenter trials to those exploring repurposing of marketed agents. Additionally, pilot studies; reports that assess drug safety and tolerability in all phases of development; new routes of administration and new formulations; pharmacokinetic, bio-availability, and biosimilarity; and changes in practice guidelines and standards, are all of interestfor publication. Clinical Therapeutics also understands the importance of strengthening the body of evidencesurrounding particular agents through the publication of replication studies, negative trials, and failed trials. Beyond the clinic, we seek reports that examine the real-world implications of therapeutics such as comparative effectiveness and pharmacoeconomics studies as well as work that has implications for health policy. Commentaries, which include perspectives and contemporary issues, are sought to offer a balance of viewpoints and scholarly opinion on a broad array of drug-related topics. Case reports, which remain a vital part of our mission, offer clinically valuable lessons. All manuscripts are peer reviewed by independent clinicians or scientists for clinical relevance, technical accuracy, methodological rigor, clarity, and objectivity using a blind review process.In addition to feature articles published monthly, each issue of Clinical Therapeutics features a specific theme section dedicated to an annual update of a specific topic area. A special guest editor will comprise each update with reviews, commentaries, and original research highlighting what's new or controversial in the topical specialty. Authors are invited to submit manuscripts for consideration in the topic updates, identifying submissions as such in their cover letters. Submissions not selected for the updates will be considered for general publication. 2019 TOPIC UPDATE CALENDAR Submit your manuscript at http://www.ees.elsevier.com/clinther

臨床治療學(xué)提供同行評審，快速公布藥物和其他療法的最新進展，以及藥物經(jīng)濟學(xué)、健康政策、治療結(jié)果以及藥物和生物制劑研究的創(chuàng)新。此外，臨床治療的特點，更新的具體主題由專家專題編輯整理。在各種研究、學(xué)術(shù)和臨床實踐環(huán)境中，國際上大量的科學(xué)家和臨床醫(yī)師閱讀臨床治療學(xué)。文章被所有主要的生物醫(yī)學(xué)文摘數(shù)據(jù)庫編入索引。已發(fā)表的文章范圍從在大型多中心試驗中探索新的化學(xué)實體的關(guān)鍵性研究到探索市場化試劑的再利用。此外，試點研究；評估所有開發(fā)階段藥物安全性和耐受性的報告；新的給藥途徑和新的制劑；藥代動力學(xué)、生物可用性和生物相似性；以及實踐指南和標準的變化，都是值得發(fā)表的。臨床治療學(xué)還了解通過發(fā)表復(fù)制研究、陰性試驗和失敗試驗來加強特定藥物周圍證據(jù)的重要性。除了臨床之外，我們還尋求研究治療學(xué)的現(xiàn)實意義的報告，如比較有效性和藥理學(xué)研究，以及對健康政策有影響的工作。評注，包括觀點和當(dāng)代問題，旨在提供一個平衡的觀點和學(xué)術(shù)意見，廣泛的毒品相關(guān)的主題。病例報告仍然是我們?nèi)蝿?wù)的重要組成部分，為臨床提供了寶貴的經(jīng)驗教訓(xùn)。所有的手稿都由獨立的臨床醫(yī)生或科學(xué)家進行同行評審，以確定臨床相關(guān)性、技術(shù)準確性、方法嚴謹性、清晰度和客觀性，并采用盲評過程。除了每月出版的專題文章外，每一期的臨床治療都有一個專門的主題部分，專門針對特定主題領(lǐng)域的年度更新。特邀編輯將包括每一個更新，包括評論、評論和原始研究，突出主題專業(yè)的新內(nèi)容或有爭議的內(nèi)容。作者被邀請在主題更新中提交手稿以供考慮，并在其附信中確定提交內(nèi)容。未選擇用于更新的提交將被視為常規(guī)發(fā)布。2019主題更新日歷在http://www.ees.elsevier.com/clinther提交您的手稿。